Ketogenic diet for the treatment of refractory epilepsy: a 10 year experience in children.
نویسندگان
چکیده
Ketogenic diet (KD) is a high fat and low carbohydrate diet, which controls refractory epilepsy. We analyzed the KD effects on 54 children of the Children's Institute of the University of São Paulo. Efficacy, tolerability, and adverse effects were studied. Response to KD was effective (E) if seizure control was >75%, good (G) when 50-75%. When possible, we correlated the results with the epileptic syndrome and patient's age. By the second month on diet, 57.4% of the patients had E response and 31.4% G results. At the 6th month, 63.8% had E response and 25.5% G. At the 12th month, 71.8% had E and 25.6% G. At the 24th month, 62.1% had E and 37.9% G. Antiepileptic drugs have been reduced, and generalized epilepsy was the most sensitive. Age-related differences were not observed. Adverse effects were rarely observed. In conclusion, KD proved to be an effective treatment for refractory epilepsy.
منابع مشابه
Assessment and follow up of the children with refractory epilepsy on ketogenic diet
Introduction: The ketogenic diet is a method of treatment that is recommended for patients with epilepsy who have not responded to medications. The present study was designed to evaluate the efficacy of the ketogenic diet along with follow-up on drug resistant epilepsy in children referred to medical centers affiliated to Shiraz University of Medical Sciences. Methods: This study was a multicen...
متن کامل[Ketogenic diet for the treatment of refractory epilepsy].
OBJECTIVES To systematically review and synthesize the available evidence on the efficacy of the ketogenic diet in reducing seizure frequency for children with refractory epilepsy. DATA SOURCES Medline searches were performed using the keywords epilepsy/therapy, dietary therapy, and epilepsy, and the text word ketogenic diet. The Cochrane Library of clinical trials was searched using the term...
متن کاملمقایسه اثر گاماگلوبولین وریدی با رژیم کتوژنیک در کودکان مبتلا به صرع مقاوم
Since of seizures in epileptic is in childhood in 80% of cases and 10 to 20% of these seizures are refractory to treatment , this study was performed ...
متن کاملEfficiency of the ketogenic diet: treatment of refractory childhood epilepsy
This review reports on the past, current and potential future developments in aspects of the ketogenic diet in epilepsy treatment for children who have refractory epilepsy (uncontrolled seizures after having tried at least two anti-epileptic drugs). The ketogenic diet is based on putting the body into ketosis, so that is uses ketones rather than glucose for the energy in the brain. The diet com...
متن کاملThe Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial
BackgroundAbout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. Melatonin is a natural pineal gland hormone. The use of melatonin for controlling pediatric seizures is still controversial. This study aimed to evaluate the effect of melatonin on seizure...
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ورودعنوان ژورنال:
- Arquivos de neuro-psiquiatria
دوره 65 2B شماره
صفحات -
تاریخ انتشار 2007